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Dendritic cell-based vaccines for pancreatic cancer and melanoma.

Authors
Type
Published Article
Journal
Annals of the New York Academy of Sciences
1749-6632
Publisher
Wiley Blackwell (Blackwell Publishing)
Publication Date
Volume
1174
Pages
33–40
Identifiers
DOI: 10.1111/j.1749-6632.2009.04936.x
PMID: 19769734
Source
Medline
License
Unknown

Abstract

Based on leads from our recent animal studies, we are embarking on a series of new clinical trials to evaluate potential improvements in dendritic cell (DC)-based vaccines for melanoma and pancreatic cancer. The first new strategy involves the use of a powerful chemokine (denoted secondary lymphoid tissue chemokine; SLC/CCL-21), which can both create functioning lymph node-like structures at sites of vaccination with tumor-loaded DCs and dramatically enhance vaccine efficacy in animal tumor models. Using this strategy, we are embarking on a clinical trial in melanoma patients with the intent to create functioning, ectopic, lymph node-like structures to enhance host antitumor immunity. The second strategy, in the setting of pancreatic cancer, involves a gene therapy and immunotherapy combination of a locally administered tumor necrosis factor-alpha gene vector followed by radiation (to induce tumor apoptosis/necrosis) and intratumorally administered monocyte-derived DCs (to uptake and present antigens from dying tumor cells to elicit potent, systemic, antitumor immunity).

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