Affordable Access

Demonstration of platelet electrophoretic mobility slowing factor (PSF) in supernatants of human lymphocyte cultures stimulated by phytohaemagglutinin (PHA).

Authors
  • Jirillo, E
  • Colucci, D
  • de Santis, A
  • Munno, I
  • Fumarola, D
Type
Published Article
Journal
Acta allergologica
Publication Date
Dec 01, 1977
Volume
32
Issue
6
Pages
373–381
Identifiers
PMID: 579539
Source
Medline
License
Unknown

Abstract

It has been demonstrated that human peripheral lymphocytes, stimulated with PHA, form or release a factor that slows platelet electrophoretic mobility (PEM). The factor is chromatographed on Ultrogel AC a 44, has a molecular weight of approximately 45,000, is stable on heating at 56 degrees C for 30 min, but is inactivated by heating at 80 degrees C for 10 min. In addition, it is distinct from leukocyte inhibiting factor, which elutes in the range of BSA (mol. wt. 69,000). The authors conclude, in accordance with previous investigations, that cellular immunity is involved in thrombotic processes.

Report this publication

Statistics

Seen <100 times