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Demonstration of the organ preference of liver selected 'high metastatic' Lewis lung tumor cell line.

Authors
  • Paku, S
  • Rot, A
  • Ladányi, A
  • Lapis, K
Type
Published Article
Journal
Clinical & experimental metastasis
Publication Date
Jan 01, 1989
Volume
7
Issue
6
Pages
599–607
Identifiers
PMID: 2776366
Source
Medline
License
Unknown

Abstract

The experimental metastasis patterns of 'low metastatic' Lewis lung tumor (LLT) and liver selected 'high metastatic' LLT-HH were studied following their arterial dissemination. In previous reports it was shown that both tumor lines develop metastases only in the first encountered organ. Here the liver preference of the liver selected cell line is demonstrated. The model of two LLT cell lines can provide experimental evidence for both the 'mechanical' and 'seed and soil' theories of metastasis formation, depending on the site of tumor cell injection.

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