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Demographic predictors of hospitalization and mortality in US children with COVID-19

Authors
  • Moreira, Alvaro1
  • Chorath, Kevin2
  • Rajasekaran, Karthik2
  • Burmeister, Fiona1
  • Ahmed, Mubbasheer3
  • Moreira, Axel3
  • 1 University of Texas Health San Antonio,
  • 2 University of Pennsylvania,
  • 3 Baylor College of Medicine,
Type
Published Article
Journal
European Journal of Pediatrics
Publisher
Springer-Verlag
Publication Date
Jan 20, 2021
Pages
1–5
Identifiers
DOI: 10.1007/s00431-021-03955-x
PMID: 33474580
PMCID: PMC7817069
Source
PubMed Central
Keywords
Disciplines
  • Short Communication
License
Unknown

Abstract

Understanding which children are at increased risk for poor outcome with COVID-19 is critical. In this study, we link pediatric population–based data from the US Center for Disease Control and Prevention to COVID-19 hospitalization and in-hospital death. In 27,045 US children with confirmed COVID-19, we demonstrate that African American [OR 2.28 (95% CI: 1.93, 2.70)] or mixed race [OR 2.95 (95% CI: 2.28, 3.82)] and an underlying medical condition [OR 3.55 (95% CI: 3.14, 4.01)] are strong predictors for hospitalization. Death occurred in 39 (0.19%) of 20,096 hospitalized children; children with a prior medical condition had an increased odd for death [OR 8.8 (95% CI: 3.7, 21.1)]. Conclusion : Hospitalization and in-hospital death are rare in children diagnosed with COVID-19. However, children at higher risk for these outcomes include those with an underlying medical condition, as well as those of African American descent. What is Known: • Demographic factors are independent prognosticators of poor outcome in children with COVID-19. What is New: • Children with an underlying medical condition and those from an African American or mixed race/ethnicity are at high risk for COVID-19 hospitalization. • History of a comorbidity supersedes age, gender, and race/ethnicity as a risk factor for in-hospital pediatric COVID-19 death.

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