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Dementia associated with vitamin B(12) deficiency: presentation of two cases and review of the literature.

Authors
  • Goebels, N
  • Soyka, M
Type
Published Article
Journal
The Journal of neuropsychiatry and clinical neurosciences
Publication Date
Jan 01, 2000
Volume
12
Issue
3
Pages
389–394
Identifiers
PMID: 10956574
Source
Medline
License
Unknown

Abstract

Vitamin B(12) deficiency has long been associated with a wide variety of hematological, neurological, and psychiatric disorders. The role of vitamin B(12) deficiency as one of the few treatable causes of dementia, however, is still controversial. The authors report on 2 elderly patients suffering from cognitive impairment and psychotic symptomatology probably related to cobalamin deficiency, who showed improvement after parenteral vitamin B(12) substitution. The literature concerning the pathophysiology and the diagnostic and therapeutic aspects of cobalamin deficiency is reviewed.

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