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{Delta}Np73{beta} puts the brakes on DNA repair.

Authors
  • Vernersson-Lindahl, Emma
  • Mills, Alea A
Type
Published Article
Journal
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Publication Date
Mar 15, 2010
Volume
24
Issue
6
Pages
517–520
Identifiers
DOI: 10.1101/gad.1914210
PMID: 20231313
Source
Medline
License
Unknown

Abstract

Mammalian cells are barraged with endogenous metabolic byproducts and environmental insults that can lead to nearly a million genomic lesions per cell per day. Networks of proteins that repair these lesions are essential for genome maintenance, and a compromise in these pathways propagates mutations that can cause aging and cancer. The p53 tumor suppressor plays a central role in repairing the effects of DNA damage, and has therefore earned the title of "guardian of the genome." In this issue of Genes & Development, Wilhelm and colleagues (pp. 549-560) demonstrate that p73-an older sibling of p53-inhibits pathways that resolve DNA double-strand breaks.

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