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Delivery of genome editing tools by bacterial extracellular vesicles

Authors
  • Liu, Yue
  • Smid, Eddy J.
  • Abee, Tjakko
  • Notebaart, Richard A.
Publication Date
Jan 01, 2019
Source
Wageningen University and Researchcenter Publications
Keywords
Language
English
License
Unknown
External links

Abstract

Here we propose to use bacterial cells as factories that generate EVs harboring both the RNP complex (or any other CRISPR‐mediated tool) and a specific ligand molecule. The ligand would allow specific binding of EVs to cells with the matching receptors, adding a level of specificity to the delivery, hence stimulating precise genome editing.

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