Affordable Access

Access to the full text

Delivery of cancer therapies by synthetic and bio-inspired nanovectors

Authors
  • Briolay, Tina1
  • Petithomme, Tacien1
  • Fouet, Morgane1
  • Nguyen-Pham, Nelly1
  • Blanquart, Christophe1
  • Boisgerault, Nicolas1
  • 1 Université de Nantes, Inserm, CRCINA, Nantes, F-44000, France , Nantes (France)
Type
Published Article
Journal
Molecular Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Mar 24, 2021
Volume
20
Issue
1
Identifiers
DOI: 10.1186/s12943-021-01346-2
Source
Springer Nature
Keywords
License
Green

Abstract

BackgroundAs a complement to the clinical development of new anticancer molecules, innovations in therapeutic vectorization aim at solving issues related to tumor specificity and associated toxicities. Nanomedicine is a rapidly evolving field that offers various solutions to increase clinical efficacy and safety.MainHere are presented the recent advances for different types of nanovectors of chemical and biological nature, to identify the best suited for translational research projects. These nanovectors include different types of chemically engineered nanoparticles that now come in many different flavors of ‘smart’ drug delivery systems. Alternatives with enhanced biocompatibility and a better adaptability to new types of therapeutic molecules are the cell-derived extracellular vesicles and micro-organism-derived oncolytic viruses, virus-like particles and bacterial minicells. In the first part of the review, we describe their main physical, chemical and biological properties and their potential for personalized modifications. The second part focuses on presenting the recent literature on the use of the different families of nanovectors to deliver anticancer molecules for chemotherapy, radiotherapy, nucleic acid-based therapy, modulation of the tumor microenvironment and immunotherapy.ConclusionThis review will help the readers to better appreciate the complexity of available nanovectors and to identify the most fitting “type” for efficient and specific delivery of diverse anticancer therapies.

Report this publication

Statistics

Seen <100 times