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Deletion of protein tyrosine phosphatase 1b improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone.

Authors
  • Ali, M Irfan
  • Ketsawatsomkron, Pimonrat
  • Belin de Chantemele, Eric J
  • Mintz, James D
  • Muta, Kenjiro
  • Salet, Christina
  • Black, Stephen M
  • Tremblay, Michel L
  • Fulton, David J
  • Marrero, Mario B
  • Stepp, David W
Type
Published Article
Journal
Circulation Research
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Nov 06, 2009
Volume
105
Issue
10
Pages
1013–1022
Identifiers
DOI: 10.1161/CIRCRESAHA.109.206318
PMID: 19797171
Source
Medline
License
Unknown

Abstract

Deletion of PTP1B improved both endothelium dependent and independent NO-mediated dilation and reduced superoxide generation in db/db mice. PTP1B deletion did not affect any vascular function in lean mice. Taken together, these data reveal a role for peripheral insulin resistance as the mediator of vascular dysfunction in obesity.

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