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Delayed testosterone replacement restores nitric oxide synthase-containing nerve fibres and the erectile response in rat penis.

Authors
  • Baba, K
  • Yajima, M
  • Carrier, S
  • Morgan, D M
  • Nunes, L
  • Lue, T F
  • Iwamoto, T
Type
Published Article
Journal
BJU international
Publication Date
May 01, 2000
Volume
85
Issue
7
Pages
953–958
Identifiers
PMID: 10792181
Source
Medline
License
Unknown

Abstract

Testosterone acts on the nervous system to mediate erection; when it is absent there may be down-regulation of both the production and activity of NO, thereby decreasing the response to peripheral stimulation via the NO pathway. The restoration of erectile function seen in rats in group 2 supports this phenomenon. Delayed testosterone replacement has no detrimental effect on the restoration of the erectile mechanism after castration.

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