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Degraded cardiomyocytes and dysfunctional energy metabolism; their relationship with canine cardiomyopathies.

Authors
Type
Published Article
Journal
Mitochondrion
1567-7249
Publisher
Elsevier
Publication Date
Volume
3
Issue
6
Pages
355–363
Identifiers
PMID: 16120367
Source
Medline
License
Unknown

Abstract

Tissue sections from hearts of dogs suffering from cardiomyopathies were studied histologically and ultrastructurally. Two types of mitochondrial changes were defined and quantitated. Mitochondrial hypertrophy occurred in cardiomyocytes of middle-aged and older dogs. Significant numbers of degraded cardiomyocytes related to hydropic degeneration of hypertrophied mitochondria associated with autolysis of contractile elements and loss of cellular physiochemical functions were seen in hearts of old dogs with cardiomyopathy. Dogs with cardiac disease that were treated to enhance dysfunctional energy production early in the course of disease had cellular changes similar to those seen in old dogs but they survived heart disease and ultimately died of other causes.

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