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The degradation of cholesterol by Pseudomonas sp. NCIB 10590 under aerobic conditions.

Authors
  • Owen, R W
  • Mason, A N
  • Bilton, R F
Type
Published Article
Journal
Journal of lipid research
Publication Date
Nov 01, 1983
Volume
24
Issue
11
Pages
1500–1511
Identifiers
PMID: 6655367
Source
Medline
License
Unknown

Abstract

The metabolic pathway of cholesterol degradation by bacteria has not been completely established. Several possible intermediates have not been identified and many pathway delineations have not involved the use of the cholesterol molecule per se and just one bacterial species. The bacterial degradation of cholesterol by Pseudomonas sp. NCIB has been studied. Major biotransformation products included cholest-5-en-3-one, cholest-4-en-3-one, 26-hydroxycholest-4-en-3-one, androsta-1, 4-dien-3-17-dione, cholest-4-en-3-one-26-oic acid, chol-4-en-3-one-24-oic acid, pregn-4-en-3-one-20-carboxylic acid, and pregna-1, 4-dien-3-one-20-carboxylic acid. Studies with selected intermediates have enabled the elucidation of a comprehensive pathway of cholesterol degradation by bacteria.

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