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Degradation of activated protein kinases by ubiquitination.

Authors
Type
Published Article
Journal
Annual Review of Biochemistry
Publisher
Annual Reviews
Volume
78
Pages
435–475
Identifiers
DOI: 10.1146/annurev.biochem.013008.092711
Source
Hunter Lab
License
Unknown

Abstract

Protein kinases are important regulators of intracellular signal transduction pathways and play critical roles in diverse cellular functions. Once a protein kinase is activated, its activity is subsequently downregulated through a variety of mechanisms. Accumulating evidence indicates that the activation of protein kinases commonly initiates their downregulation via the ubiquitin/proteasome pathway. Failure to regulate protein kinase activity or expression levels can cause human diseases.

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