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Definition of period of induction of deciduoma in the rat using ornithine decarboxylase as a marker of growth onset.

Authors
  • Barkai, U
  • Kraicer, P F
Type
Published Article
Journal
International journal of fertility
Publication Date
Jan 01, 1978
Volume
23
Issue
2
Pages
106–111
Identifiers
PMID: 30718
Source
Medline
License
Unknown

Abstract

The activity of uterine ornithine decarboxylase (ODC) was measured during the 24 hours after systemic induction of decidualization. Following a latent period of 2.5 hours, activity rose and reached a peak of 5.6 +/- 1.1 fold at 5 hours after induction. The activity then declined and a second, lower peak was seen at 21 hours. The increase in ODC activity was suppressed by treatment with cycloheximide (50 mg/kg) and dactinomycin, 500 microgram/rat, confirming that the enzyme response reflects protein synthesis. The increase and the base-line level of ODC activity were suppressed by ergocornine pretreatment (1 mg/rat) which disturbs the endocrine balance of pseudopregnancy. It was concluded that the growth and differentiation of decidual tissue began 2.5 hours after application of the induction stimulus.

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