Affordable Access

Defining the dynamics of self-assembled Fas-receptor activation.

Authors
Type
Published Article
Journal
Trends in Immunology
1471-4906
Publisher
Elsevier
Publication Date
Volume
23
Issue
4
Pages
187–194
Identifiers
PMID: 11923113
Source
Medline
License
Unknown

Abstract

Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled function. In this review, we attempt to develop such a perspective on the regulation of Fas signaling. The multistep Fas regulation model presented here should be helpful in devising effective interventions for conditions resulting from the dysregulation of Fas.

Statistics

Seen <100 times