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Deficit of somatostatin-like immunoreactivity in the vitreous fluid of diabetic patients: possible role in the development of proliferative diabetic retinopathy.

Authors
  • Simó, Rafael
  • Lecube, Albert
  • Sararols, Laura
  • García-Arumí, José
  • Segura, Rosa M
  • Casamitjana, Roser
  • Hernández, Cristina
Type
Published Article
Journal
Diabetes Care
Publisher
American Diabetes Association
Publication Date
Dec 01, 2002
Volume
25
Issue
12
Pages
2282–2286
Identifiers
PMID: 12453974
Source
Medline
License
Unknown

Abstract

The significantly higher SLI in the vitreous fluid than in plasma detected in nondiabetic control subjects supports the concept that somatostatin plays a relevant role in retinal homeostasis. In addition, the intravitreous deficit of SLI observed in diabetic patients with PDR suggests that it might contribute to the process of retinal neovascularization.

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