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Deficiency of acyl CoA cholesterol acyl transferase activity in suncus liver.

Authors
  • Nagayoshi, A
  • Matsuki, N
  • Saito, H
  • Tsukamoto, K
  • Wakashima, M
  • Kinoshita, M
  • Yamanaka, M
  • Teramoto, T
Type
Published Article
Journal
Journal of biochemistry
Publication Date
May 01, 1994
Volume
115
Issue
5
Pages
858–861
Identifiers
PMID: 7961598
Source
Medline
License
Unknown

Abstract

We reported previously that apolipoprotein B is not actively secreted from suncus liver. In the present study we have investigated the hepatic cholesterol metabolism, which plays a critical role in the secretion of apo B. We found that the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in suncus liver is high and that acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity is almost absent in contrast to rats. As a result, the hepatic content of cholesterol ester, upon which apoprotein B secretion partly depends, is very low in suncus. The deficiency of ACAT activity may cause the defect in active secretion of apoprotein B-containing lipoproteins in suncus.

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