[Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis].
Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- Published Article
The Korean journal of hepatology
- Publication Date
Jun 01, 2010
Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.
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The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/20606502