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[Deficiencies in proteins C and S in a patient with idiopathic portal hypertension accompanied by portal vein thrombosis].

Authors
  • Hwang, Sena1
  • Kim, Do Young
  • Kim, Minju
  • Chon, Young Eun
  • Lee, Hyun Jung
  • Park, Young-Nyun
  • Park, Jun Yong
  • Ahn, Sang Hoon
  • Han, Kwang-Hyub
  • Chon, Chae Yoon
  • 1 Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. , (North Korea)
Type
Published Article
Journal
The Korean journal of hepatology
Publication Date
Jun 01, 2010
Volume
16
Issue
2
Pages
176–181
Identifiers
DOI: 10.3350/kjhep.2010.16.2.176
PMID: 20606502
Source
Medline
License
Unknown

Abstract

Portal vein thrombosis (PVT) is an uncommon cause of presinusoidal portal hypertension. Among various hepatoportal disorders, noncirrhotic portal hypertension conditions such as idiopathic portal hypertension (IPH) are considered to have a close relation with PVT. PVT is known to have several predisposing conditions, including infection, malignancies, and coagulation disorders. There is growing interest and recognition that deficiencies in proteins C and S are associated with a hypercoagulable state. These deficiencies are regarded as key factors of systemic hypercoagulability and recurrent venous thromboembolism. We report the case of a 19-year-old male diagnosed as IPH with PVT and combined deficiencies in proteins C and S.

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