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Defective epidermal innate immunity and resultant superficial dermatophytosis in adult T-cell leukemia/lymphoma.

Authors
  • Sawada, Yu
  • Nakamura, Motonobu
  • Kabashima-Kubo, Rieko
  • Shimauchi, Takatoshi
  • Kobayashi, Miwa
  • Tokura, Yoshiki
Type
Published Article
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
Publication Date
Jul 15, 2012
Volume
18
Issue
14
Pages
3772–3779
Identifiers
DOI: 10.1158/1078-0432.CCR-12-0292
PMID: 22648272
Source
Medline
License
Unknown

Abstract

Taken together, these results suggest that the keratinocyte production of antimicrobial peptides promoted by Th17 cells is reduced in ATLL patients, leading to the perturbed innate immunity and the frequent occurrence of superficial dermatophytosis.

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