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Defective cellular localization of mutant ATP7B in Wilson's disease patients and hepatoma cell lines.

Authors
  • Huster, Dominik
  • Hoppert, Michael
  • Lutsenko, Svetlana
  • Zinke, Jan
  • Lehmann, Claudia
  • Mössner, Joachim
  • Berr, Frieder
  • Caca, Karel
Type
Published Article
Journal
Gastroenterology
Publisher
Elsevier
Publication Date
Feb 01, 2003
Volume
124
Issue
2
Pages
335–345
Identifiers
PMID: 12557139
Source
Medline
License
Unknown

Abstract

These results provide a detailed demonstration of the ATP7B distribution in control and diseased human livers and indicate that several Wilson's disease mutations lead to incorrect localization of ATP7B to distinct cell compartments.

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