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Defect of adaptation to hypoxia in patients with COPD due to reduction of histone deacetylase 7.

Authors
  • To, Masako1
  • Yamamura, Satoshi2
  • Akashi, Kenichi2
  • Charron, Catherine E2
  • Haruki, Kosuke3
  • Barnes, Peter J2
  • Ito, Kazuhiro4
  • 1 Airway Disease Section, National Heart and Lung Institute, Imperial College, London, England; Department of Laboratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya-City, Saitama, Japan. , (Japan)
  • 2 Airway Disease Section, National Heart and Lung Institute, Imperial College, London, England.
  • 3 Department of Laboratory Medicine, Dokkyo Medical University Koshigaya Hospital, Koshigaya-City, Saitama, Japan. , (Japan)
  • 4 Airway Disease Section, National Heart and Lung Institute, Imperial College, London, England. Electronic address: [email protected]
Type
Published Article
Journal
CHEST Journal
Publisher
Elsevier
Publication Date
May 2012
Volume
141
Issue
5
Pages
1233–1242
Identifiers
DOI: 10.1378/chest.11-1536
PMID: 22172637
Source
Medline
License
Unknown

Abstract

HDAC7 reduction in COPD causes a defect of HIF-1α induction response to hypoxia with impaired VEGF gene expression. This poor cellular adaptation might play a role in the pathogenesis of COPD.

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