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A defect in nurturing in mice lacking the immediate early gene fosB.

Authors
Type
Published Article
Journal
Cell
0092-8674
Publisher
Elsevier
Publication Date
Volume
86
Issue
2
Pages
297–309
Identifiers
PMID: 8706134
Source
Medline
License
Unknown

Abstract

Although expression of the Fos family of transcription factors is induced by environmental stimuli that trigger adaptive neuronal response, evidence that Fos family members mediate these responses is lacking. To address this issue, mice were generated with an inactivating mutation in the fosB gene. fosB mutant mice are profoundly deficient in their ability to nurture young animals but are normal with respect to other cognitive and sensory functions. The nurturing defect is likely due to the absence of FosB in the preoptic area, a region of the hypothalamus that is critical for nurturing. These observations suggest that a transcription factor controls a complex behavior by regulating a specific neuronal circuit and indicate that nurturing in mammals has a genetic component.

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