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Hyperosmotic arabinose solutions open the tight junctions between brain capillary endothelial cells in tissue culture

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
302
Issue
2
Identifiers
DOI: 10.1016/0006-8993(84)90254-3
Keywords
  • Brain Capillary Endothelium
  • Tight Junctions
  • Arabinose
  • Horseradish Peroxidase

Abstract

Abstract Tight junctions between bovine brain capillary endothelial cells in primary cell culture are impermeable to horseradish peroxidase (HRP) after 5 min of incubation. However, following 1–5 min of exposure to 1.6 M arabinose, HRP penetrates the extracellular space between successive tight junctions. Endothelial cells in control cultures contain a small number of cytoplasmic pits and vesicles containing HRP which do not increase in number after hyperosmotic treatment.

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