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Decreased in vitro proliferation of bladder epithelial cells from patients with interstitial cystitis.

Authors
  • Keay, Susan
  • Zhang, Chen-Ou
  • Shoenfelt, Joanna L
  • Chai, Toby C
Type
Published Article
Journal
Urology
Publisher
Elsevier
Publication Date
Jun 01, 2003
Volume
61
Issue
6
Pages
1278–1284
Identifiers
PMID: 12809929
Source
Medline
License
Unknown

Abstract

The proliferation rate of explanted bladder epithelial cells from patients with IC in serum-free medium was significantly less than that of control cells, indicating an intrinsic abnormality in IC cell proliferation. This abnormality may be caused by APF, which induces reversible inhibition of heparin-binding epidermal growth factor-like growth factor production and normal bladder epithelial cell proliferation.

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