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Decreased response to catecholamines in the newborn: effect on glucose kinetics in the lamb.

Authors
Type
Published Article
Journal
Metabolism
0026-0495
Publisher
Elsevier
Publication Date
Volume
37
Issue
8
Pages
736–740
Identifiers
PMID: 3043145
Source
Medline
License
Unknown

Abstract

Epinephrine, a catecholamine with both alpha (alpha) and beta (beta) adrenergic effects, may produce hyperglycemia in adults by increasing glucose production and decreasing glucose clearance. To document the degree of sensitivity and characterize maturation of neonatal glucose control, glucose kinetics were measured in 14 term newborn lambs (weight 4.5 +/- 0.3 kg [mean +/- SEM] and aged 4.1 +/- 0.4 days). Following infusion of 0.9% NaCl at 0.06 mg.kg-1 min-1 plus 100 microCi/kg D[6-3H] glucose by prime plus constant infusion, rate of production (Ra) and glucose clearance were measured during administration of epinephrine. The responses in the newborns were compared with those in six adult sheep. Under conditions of epinephrine infusion, the plasma glucose concentration in the newborn lambs increased to 129 +/- 18 mg/dL (50 ng.kg-1 min-1 epinephrine), P less than .0001, and 253 +/- 8 mg/dL (500 ng.kg-1 min-1 epinephrine), P less than .0001, compared with 95 +/- 8 mg/dL (controls, no epinephrine). Comparable values for Ra were 6.5 +/- 1.6 mg.kg-1 min-1 (50 ng.kg-1 min-1 epinephrine), P = NS, and 18.5 +/- 3.0 mg.kg-1 min-1 (500 ng.kg-1 min-1 epinephrine), P less than .0001, compared with 5.3 +/- 0.5 mg.kg-1 min-1 (controls, no epinephrine).(ABSTRACT TRUNCATED AT 250 WORDS)

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