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Decreased protein levels of key insulin signalling molecules in adipose tissue from young men with a low birthweight: potential link to increased risk of diabetes?

Authors
  • Ozanne, S E
  • Jensen, C B
  • Tingey, K J
  • Martin-Gronert, M S
  • Grunnet, L
  • Brons, C
  • Storgaard, H
  • Vaag, A A
Type
Published Article
Journal
Diabetologia
Publication Date
Dec 01, 2006
Volume
49
Issue
12
Pages
2993–2999
Identifiers
PMID: 17063325
Source
Medline
License
Unknown

Abstract

These findings show that low birthweight is associated with reduced levels of adipose insulin signalling proteins, thus providing a potential molecular framework to explain why people with low birthweight are at increased risk of developing type 2 diabetes. These differences precede the development of diabetes and thus may help predict disease risk.

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