Affordable Access

Access to the full text

Decreased Platelet Counts and Serum Levels of VEGF-A, PDGF-BB, and BDNF in Extremely Preterm Infants Developing Severe ROP

Authors
  • Hellgren, Gunnel
  • Lundgren, Pia
  • Pivodic, Aldina
  • Löfqvist, Chatarina
  • Nilsson, Anders K.
  • Ley, David
  • Sävman, Karin
  • Smith, Lois E.
  • Hellström, Ann
Type
Published Article
Journal
Neonatology
Publisher
S. Karger AG
Publication Date
Feb 19, 2021
Volume
118
Issue
1
Pages
18–27
Identifiers
DOI: 10.1159/000512282
PMID: 33611321
Source
Karger
Keywords
License
Green
External links

Abstract

Introduction: Thrombocytopenia has been identified as an independent risk factor for retinopathy of prematurity (ROP), although underlying mechanisms are unknown. In this study, the association of platelet count and serum platelet-derived factors with ROP was investigated. Methods: Data for 78 infants born at gestational age (GA) <28 weeks were included. Infants were classified as having no/mild ROP or severe ROP. Serum levels of vascular endothelial growth factor A, platelet-derived growth factor BB, and brain-derived neurotrophic factor were measured in serum samples collected from birth until postmenstrual age (PMA) 40 weeks. Platelet counts were obtained from samples taken for clinical indication. Results: Postnatal platelet counts and serum concentrations of the 3 growth factors followed the same postnatal pattern, with lower levels in infants developing severe ROP at PMA 32 and 36 weeks (p < 0.05–0.001). With adjustment for GA, low platelet counts and low serum concentrations of all 3 factors at PMA 32 weeks were significantly associated with severe ROP. Serum concentrations of all 3 factors also strongly correlated with platelet count (p < 0.001). Conclusion: In this article, we show that ROP, platelet counts, and specific pro-angiogenic factors correlate. These data suggest that platelet-released factors might be involved in the regulation of retinal and systemic angiogenesis after extremely preterm birth. Further investigations are needed.

Report this publication

Statistics

Seen <100 times