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Decreased phenotypic susceptibility to etravirine in patients with predicted genotypic sensitivity.

Authors
  • Agneskog, Eva
  • Nowak, Piotr
  • Maijgren Steffensson, Catharina
  • Casadellà, Maria
  • Noguera-Julian, Marc
  • Paredes, Roger
  • Källander, Clas F R
  • Sönnerborg, Anders
Type
Published Article
Journal
PLoS ONE
Publisher
Public Library of Science
Publication Date
Jan 01, 2014
Volume
9
Issue
7
Identifiers
DOI: 10.1371/journal.pone.0101508
PMID: 25000302
Source
Medline
License
Unknown

Abstract

The RT-based phenotypic assay showed decreased ETR susceptibility in patients where direct sequencing predicted ETR-sensitive virus. This increased phenotypic sensitivity was to a large extent supported by UDPS and treatment history. Our method could be valuable for further studies on the phenotypic kinetics of NNRTI resistance. The clinical relevance remains to be studied in larger patient-populations.

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