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Decreased levels of folate receptor-β and reduced numbers of fetal macrophages (Hofbauer cells) in placentas from pregnancies with severe pre-eclampsia.

Authors
  • Tang, Zhonghua
  • Buhimschi, Irina A
  • Buhimschi, Catalin S
  • Tadesse, Serkalem
  • Norwitz, Errol
  • Niven-Fairchild, Tracy
  • Huang, Se-Te J
  • Guller, Seth
Type
Published Article
Journal
American journal of reproductive immunology (New York, N.Y. : 1989)
Publication Date
Aug 01, 2013
Volume
70
Issue
2
Pages
104–115
Identifiers
DOI: 10.1111/aji.12112
PMID: 23480364
Source
Medline
Keywords
License
Unknown

Abstract

Severe PE is associated with decreased placental expression of FR-β and a reduction in the number of HBCs. Reduced placental macrophage function is likely to play a key role in the pathophysiology of PE.

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