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Decreased expression of MUC2 due to a decrease in the expression of lectins and apoptotic defects in colitis patients.

Authors
  • Wibowo, Agung A1, 2
  • Pardjianto, Bambang3
  • Sumitro, Sutiman B4
  • Kania, Nia5
  • Handono, Kusworini6
  • 1 Doctoral Program in Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, Indonesia. , (Indonesia)
  • 2 Department of Surgery, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. , (Indonesia)
  • 3 Department of Plastic Surgery, Faculty of Medicine Universitas Brawijaya/dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia. , (Indonesia)
  • 4 Department of Biology, Faculty of Sciences, Universitas Brawijaya Malang, East Java, Indonesia. , (Indonesia)
  • 5 Department of Pathology, Ulin General Hospital, Medical Faculty, Lambung Mangkurat University, Banjarmasin, South Kalimantan, Indonesia. , (Indonesia)
  • 6 Department of Clinical Pathology, Faculty of Medicine Universitas Brawijaya/dr.Saiful Anwar General Hospital, Malang, East Java, Indonesia. , (Indonesia)
Type
Published Article
Journal
Biochemistry and biophysics reports
Publication Date
Sep 01, 2019
Volume
19
Pages
100655–100655
Identifiers
DOI: 10.1016/j.bbrep.2019.100655
PMID: 31198858
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The involvement of mucin, lectin, and apoptosis in colitis is still unclear. This study aimed to investigate changes in MUC2 expression, inflammation, and changes in lectin expression in colitis patients. A total of 17 patients were divided into two groups including 11 hemorrhoid patients as a control group and 6 colitis patients. MUC2 mutation analysis was carried out using immunofluorescent and FISH techniques. Assessment of caspase-3, Ki-67, NF-kB, and lectin expressions was also carried out by immunofluorescent technique then analyzed by confocal laser scanning microscope. The MUC2, caspase-3, and lectin expressions were significantly lower in the colitis group than in the control group (p < 0.05). It was concluded that in colitis there was a change in MUC2 expression due to changes in lectins accompanied by apoptotic defects.conclusion.

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