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Decreased blood flow in a papaverine-induced passive vascular bed in sclerodermal skin.

Authors
Type
Published Article
Journal
Acta Dermato Venereologica
0001-5555
Publisher
Acta Dermato-Venereologica
Publication Date
Volume
59
Issue
2
Pages
145–147
Identifiers
PMID: 84492
Source
Medline
License
Unknown

Abstract

Blood flow was measured in the form of 133Xenon washout rate constants in a cutaneous vascular bed made passive by intracutaneous injection of a 133Xenon-papaverine mixture. Experiments were performed using injection volumes of 0.005, 0.02, 0.1 and 0.2 ml in 7 normals and 15 patients suffering from generalized scleroderma. Blood flow was closely related to the volume of fluid injected, probably reflecting dilution of tissues and increased diffusion distances when injection volumes were increased. When using injection volumes of 0.005 and 0.02 ml, blood flow was significantly reduced in the patients, as compared with normals, probably because of a decreased capillary density in cutaneous tissue in generalized scleroderma.

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