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Decompressive craniectomy for the treatment of malignant infarction of the middle cerebral artery.

Authors
  • Lu, XiaoCheng1
  • Huang, BaoSheng2
  • Zheng, JinYu3
  • Tao, Yi1
  • Yu, Wan4
  • Tang, LinJun1
  • Zhu, RongLan1
  • Li, Shuai1
  • Li, LiXin1
  • 1 Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China. , (China)
  • 2 Department of Neurosurgery, Sir Run Run Shaw Hospital, Nanjing Medical University, Long Mian Road, Nanjing, Jiangsu, 211166, China. , (China)
  • 3 1] Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu, 210029, China [2] Department of Neurosurgery, The Affiliated Huai'an Hospital of Xuzhou Medical College, No. 62 South Huaihai Road, Huai'an, 223002, China. , (China)
  • 4 Department of Neurosurgery, Jiangsu Province Hospital on the Intergration of Chinese and Western Medicine, Nanjing university of Traditional Chinese Medicine, Nanjing, 210028, China. , (China)
Type
Published Article
Journal
Scientific Reports
Publisher
Springer Nature
Publication Date
Nov 17, 2014
Volume
4
Pages
7070–7070
Identifiers
DOI: 10.1038/srep07070
PMID: 25400113
Source
Medline
License
Unknown

Abstract

Early decompressive craniectomy (DC) has been shown to reduce mortality in malignant middle cerebral artery (MCA) infarction, whereas efficacy of DC on functional outcome is inconclusive. Here, we performed a meta-analysis to estimate the effects of DC on malignant MCA infarction and investigated whether age of patients and timing of surgery influenced the efficacy. We systematically searched PubMed, Medline, Embase, Cochrane library, Web of Science update to June 2014. Finally, A total of 14 studies involved 747 patients were included, of which 8 were RCTs (341 patients). The results demonstrated that early DC (within 48 h after stroke onset) decreased mortality (OR = 0.14, 95%CI = 0.08, 0.25, p<0.0001) and number of patients with poor functional outcome (modified Rankin scale (mRS)>3) (OR = 0.38, 95%CI = 0.20, 0.73, p = 0.004) for 12 months follow-up. In the subgroup analysis stratified by age, early DC improved outcome both in younger and older patients. However, later DC (after 48h after stroke onset) might not have a benefit effect on lowering mortality or improving outcome in patients with malignant infarction. Together, this study suggested that decompressive surgery undertaken within 48 h reduced mortality and increased the number of patients with a favourable outcome in patients with malignant MCA infarction.

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