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Deciphering the genetic structure of the Quebec founder population using genealogies.

Authors
  • Gagnon, Laurence1, 2
  • Moreau, Claudia1, 2
  • Laprise, Catherine1, 2, 3
  • Vézina, Hélène2, 4, 5
  • Girard, Simon L6, 7, 8
  • 1 Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. , (Canada)
  • 2 Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. , (Canada)
  • 3 Centre Intégré Universitaire en Santé et Services Sociaux du Saguenay-Lac-Saint-Jean, Saguenay, Québec, G7H 7K9, Canada. , (Canada)
  • 4 Département des Sciences Humaines et Sociales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. , (Canada)
  • 5 Projet BALSAC, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. , (Canada)
  • 6 Département des Sciences Fondamentales, Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. [email protected]. , (Canada)
  • 7 Centre Intersectoriel en Santé Durable (CISD), Université du Québec à Chicoutimi, Saguenay, Québec, G7H 2B1, Canada. [email protected]. , (Canada)
  • 8 Centre de Recherche CERVO, Université Laval, Québec, Québec, G1V 0A6, Canada. [email protected]. , (Canada)
Type
Published Article
Journal
European Journal of Human Genetics
Publisher
Springer Nature
Publication Date
Jan 01, 2024
Volume
32
Issue
1
Pages
91–97
Identifiers
DOI: 10.1038/s41431-023-01356-2
PMID: 37016017
Source
Medline
Language
English
License
Unknown

Abstract

Using genealogy to study the demographic history of a population makes it possible to overcome the models and assumptions often used in population genetics. The Quebec founder population is one of the few populations in the world having access to the complete genealogy of the last 400 years. The goal of this study is to follow the evolution of the Quebec population structure over time from the beginning of European colonization until the present day. To do so, we calculated the kinship coefficients of all ancestors' pairs in the ascending genealogy of 665 subjects from eight regional and ethnocultural groups per 25-year period. We show that the Quebec population structure appeared progressively in the St. Lawrence valley as early as 1750 with the distinction of the Saguenay and Gaspesian groups. At that time, the ancestors of two groups, the Sagueneans and the Acadians from the Gaspé Peninsula, experienced a marked increase in kinship and inbreeding levels which have shaped the structure and led to the contemporary population structure. Interestingly, this structure arose before the colonization of the Saguenay region and at the very beginning of the Gaspé Peninsula settlement. The resulting regional founder effects in these groups led to differences in the present-day identity-by-descent sharing, the Gaspé and North Shore groups sharing more large segments and the Sagueneans more short segments. This is also reflected by the distribution of the number of most recent common ancestors at different generations and their genetic contribution to the studied subjects. © 2023. The Author(s).

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