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Decellularized ECM-derived bioinks: Prospects for the future.

Authors
  • Kabirian, Fatemeh1
  • Mozafari, Masoud2
  • 1 Bioengineering Research Group, Nanotechnology & Advanced Materials Department, Materials & Energy Research Center (MERC), Tehran, Iran. , (Iran)
  • 2 Bioengineering Research Group, Nanotechnology & Advanced Materials Department, Materials & Energy Research Center (MERC), Tehran, Iran; Cellular and Molecular Research Center, Iran University of Medical Sciences (IUMS), Tehran, Iran; Department of Tissue Engineering & Regenerative Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences (IUMS), Tehran, Iran. Electronic address: [email protected] , (Iran)
Type
Published Article
Journal
Methods
Publisher
Elsevier
Publication Date
Jan 15, 2020
Volume
171
Pages
108–118
Identifiers
DOI: 10.1016/j.ymeth.2019.04.019
PMID: 31051254
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Decellularization aims to remove cells from tissue ultrastructure while preserving the mechanical and biological properties, which makes the decellularized extracellular matrix (dECM) an appropriate scaffold for tissue engineering applications. Three-dimensional (3D) bioprinting technology as a reproducible and accurate method can print the combination of ECM and autologous cells layer by layer to fabricate patient based cell-laden structures representing the intrinsic cues of natural ECM. This review defines ECM, classifies decellularization agents and techniques, and explains different sources of ECM. Then, bioprinting techniques, bioink concept, applications of dECM bioinks, and finally the future perspectives of 3d bioprinting technology are discussed. Copyright © 2019 Elsevier Inc. All rights reserved.

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