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The susceptibility of T5-TG12 of theCFTRgene in chronic bronchitis occurrence in a Chinese population in Jiangsu province, China

Authors
Journal
Journal of Biomedical Research
1674-8301
Publisher
Journal of Biomedical Research
Volume
26
Issue
6
Identifiers
DOI: 10.7555/jbr.26.20120015
Keywords
  • Cystic Fibrosis Transmembrane Conductance Regulator (Cftr)
  • T5-Tg12
  • Chronic Bronchitis
  • Chinese Population

Abstract

Abstract Mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders. In the present study, we investigated the role of CFTR variations, poly-T, TG-repeats, and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province, China. A total of 72 bronchial asthma patients, 68 chronic bronchitis patients, and 117 healthy subjects were included in this study. The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism (RFLP). We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%, which was notably higher than that in healthy subjects (0.01%) and bronchial asthma patients (0.04%). Thus, the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions, such as chronic bronchitis.

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