Affordable Access

deepdyve-link
Publisher Website

Deaths associated with human adenovirus-14p1 infections, Europe, 2009-2010.

Authors
  • Carr, Michael J
  • Kajon, Adriana E
  • Lu, Xiaoyan
  • Dunford, Linda
  • O'Reilly, Paul
  • Holder, Paul
  • De Gascun, Cillian F
  • Coughlan, Suzie
  • Connell, Jeff
  • Erdman, Dean D
  • Hall, William W
Type
Published Article
Journal
Emerging Infectious Diseases
Publisher
Centers For Disease Control and Prevention
Publication Date
Aug 01, 2011
Volume
17
Issue
8
Pages
1402–1408
Identifiers
DOI: 10.3201/eid1708.101760
PMID: 21801616
Source
Medline
License
Unknown

Abstract

Human adenovirus (HAdV) serotype 14 is rarely identified. However, an emerging variant, termed HAdV-14p1, recently has been described in the United States in association with outbreaks of acute respiratory disease with high rates of illness and death. We retrospectively analyzed specimens confirmed positive for HAdV by immunofluorescence, virus culture, or real-time PCR during July 1, 2009-July 31, 2010, and describe 9 cases of HAdV-14p1 infection with characteristic mutations in the fiber and E1A genes that are phylogenetically indistinguishable from the viruses previously detected in the United States. Three patients died; 2 were immunocompromised, and 1 was an immunocompetent adult. We propose that surveillance should be increased for HAdV-14p1 and recommend that this virus be considered in the differential diagnosis of sudden-onset acute respiratory disease, particularly fatal infections, for which an etiology is not clear.

Report this publication

Statistics

Seen <100 times