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Death sentence: The tale of a fallen endoplasmic reticulum

Authors
  • McGrath, Eoghan P
  • Centonze, Federica G
  • Chevet, Eric
  • Avril, Tony
  • Lafont, Elodie
Publication Date
May 01, 2021
Identifiers
DOI: 10.1016/j.bbamcr.2021.119001
PMID: 33705817
OAI: oai:HAL:hal-03194479v1
Source
HAL
Keywords
Language
English
License
Unknown
External links

Abstract

Endoplasmic Reticulum (ER) stress signaling is an adaptive mechanism triggered when protein folding demand overcomes the folding capacity of this compartment, thereby leading to the accumulation of improperly folded proteins. This stress signaling pathway is named the Unfolded Protein Response (UPR) and aims at restoring ER homeostasis. However, if this fails, mechanisms orienting cells towards death processes are initiated. Herein, we summarize the most recent findings connecting ER stress and the UPR with identified death mechanisms including apoptosis, necrosis, pyroptosis, ferroptosis, and autophagy. We highlight new avenues that could be investigated and controlled through actionable mechanisms in physiology and pathology.

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