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Naloxone antagonizes behavioural effects ofd-amphetamine in mice and rats

Authors
Journal
Neuropharmacology
0028-3908
Publisher
Elsevier
Publication Date
Volume
17
Issue
12
Identifiers
DOI: 10.1016/0028-3908(78)90031-x
Keywords
  • Amphetamine
  • Naloxone
  • Locomotor Activity
  • Circling Behaviour

Abstract

Abstract The influence of naloxone on two characteristic behavioural effects of d-amphetamine has been studied in rodents. Naloxone (0.3, 1 and 3 mg/kg, s.c.) antagonized the increase in spontaneous locomotor activity that is associated with administration of d-amphetamine (2 mg/kg, s.c.) to mice. Naloxone, at 0.3, 1 and 3 mg/kg, subcutaneously (but not at 10 and 30 mg/kg), antagonized d-amphetamine-induced ipsilateral turning in rats lesioned unilaterally with 6-hydroxydopamine in the substantia nigra. It may be postulated that the effect of d-amphetamine in these behavioural models is brought about partially by its activity in releasing an endogenous opiate which acts via an opiate receptor influencing dopaminergic activity (naloxone sensitive) and partially by its activity on dopaminergic neurones (naloxone insensitive).

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