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Reduction of urinary bile alcohol excretion and serum cholestanol in patients with cerebrotendinous xanthomatosis after oral administration of deoxycholic acid

Authors
Journal
Clinica Chimica Acta
0009-8981
Publisher
Elsevier
Publication Date
Volume
193
Issue
3
Identifiers
DOI: 10.1016/0009-8981(90)90242-k
Keywords
  • Cerebrotendinous Xanthomatosis
  • Urinary Bile Alcohol
  • Serum Cholestanol
  • Deoxycholic Acid Therapy
Disciplines
  • Medicine

Abstract

Abstract Deoxycholic acid and chenodeoxycholic acid were administered alternately to four patients with cerebrotendinous xanthomatosis. During this oral therapy serum cholestanol and urinary bile alcohols were determined. Both showed a marked decrease after the start of the two different therapies. It can be concluded that not only chenodeoxycholic acid but also deoxycholic acid is able to suppress endogenous human bile acid synthesis, which is in accordance with other experiments describing the effect of feeding of various bile acids on endogenous bile acid synthesis.

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