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Application of Laboratory Research in UTI

Authors
Journal
EAU Update Series
1570-9124
Publisher
Elsevier
Publication Date
Volume
2
Issue
3
Identifiers
DOI: 10.1016/j.euus.2004.06.004
Keywords
  • Escherichia Coli
  • Urinary Tract Infections
  • Virulence Factors
  • Host Response
  • Laboratory Techniques
  • Uti Study Models
Disciplines
  • Biology
  • Engineering
  • Medicine

Abstract

Abstract With the development of molecular biology, new techniques in urinary tract infection (UTI) research have been introduced. This article reports on study models, molecular techniques and genetic engineering presently used in studies on UTI pathogenesis. Recent research is reviewed, and molecular bacterial virulence mechanisms and the role of inflammation in the antibacterial defenses are discussed. Pivotal studies are presented in more detail to demonstrate the use of the new methods: the in vivo investigation of bacterial virulence factors and host interaction in a human colonization protocol; the experimental mouse UTI model where mice strains differing in genetics demonstrate selective dysfunctions; the search for human polymorphism explaining suceptibility to infectious diseases.

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