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De Novo Development of Distal Jejunal and Duodenal Adenomas After 41 Months of Teduglutide Treatment in a Patient With Short-Bowel Syndrome: A Case Report.

Authors
  • Pevny, Sophie1
  • Pape, Ulrich-Frank1, 2
  • Elezkurtaj, Sefer3
  • Rieger, Anja3
  • Jürgensen, Christian1
  • Blüthner, Elisabeth1
  • Jochum, Christoph1
  • Tacke, Frank1
  • Maasberg, Sebastian2
  • 1 Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Medical Department, Division of Hepatology and Gastroenterology, Berlin, Germany. , (Germany)
  • 2 Asklepios Klinik St. Georg, Department of Internal Medicine and Gastroenterology, Hamburg, Germany. , (Germany)
  • 3 Charité - Universitätsmedizin Berlin, Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin, Institute of Health, Institute of Pathology, Berlin, Germany. , (Germany)
Type
Published Article
Journal
JPEN. Journal of parenteral and enteral nutrition
Publication Date
Aug 02, 2020
Identifiers
DOI: 10.1002/jpen.1982
PMID: 32740933
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The glucagon-like peptide-2 (GLP-2) analogue teduglutide is a medical treatment option for patients with short-bowel syndrome-associated chronic intestinal failure. Because studies in mice have shown that GLP-2 analogues may promote the growth of colonic neoplasms, surveillance colonoscopies before and during teduglutide therapy were recommended. The occurrence of small-intestinal neoplasms has not been reported so far, except for a recent report about de novo development of hamartomatous duodenal polyps. We report a case of de novo development of small-intestinal premalignant adenomatous polyps in both bulbar duodenum and distal jejunum in a patient treated with teduglutide for 41 months. Therefore, additional endoscopic surveillance of the upper gastrointestinal tract may be advised during teduglutide therapy for early detection and removal of potential small-bowel adenomas. © 2020 American Society for Parenteral and Enteral Nutrition.

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