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Authors
Publisher
Elsevier Inc.
Identifiers
DOI: 10.1016/b978-0-12-386454-3.00655-2
Keywords
  • Acetylcholinesterase Inhibitor
  • Atropine
  • Chemical Warfare Agent
  • Ga
  • G-Series Agent
  • Nerve Agent
  • Organophosphate
  • Organophosphorus
  • Pralidoxime Chloride
  • Tabun
Disciplines
  • Chemistry
  • Medicine

Abstract

Abstract Tabun is an organophosphorus nerve agent used in chemical warfare. The first of the nerve agents to be described, it was synthesized by German scientist Dr Gerhard Schrader in 1936. It is an oily liquid at room temperature, and exposure can occur via inhalation of aerosolized agent, or skin or eye contact with liquid or aerosolized agent, with signs and symptoms ranging in severity depending on the route and amount of exposure. It is an irreversible cholinesterase inhibitor, and signs and symptoms of exposure result from cholinergic overstimulation. Toxic effects include miosis, difficulty breathing, convulsions, nausea, excessive sweating, and death resulting from a cessation of breathing. Anticholinergic drugs, oximes, and anticonvulsant drugs are effective therapies if administered shortly after exposure.

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