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Physiologic role of interleukin-1 receptor antagonist

Authors
Journal
Arthritis Research
1465-9905
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
2
Issue
4
Identifiers
DOI: 10.1186/ar94
Keywords
  • Commentary
Disciplines
  • Medicine

Abstract

Recent studies have described the spontaneous development of arthritis or vasculitis in IL-1 receptor antagonist (IL-1Ra) knockout mice bred on specific and different genetic backgrounds. The levels of both secreted and intracellular isoforms of IL-1Ra produced in the rheumatoid joint or in the arterial wall may not be adequate to effectively inhibit the excess amounts of locally produced IL-1. Thus, an imbalance between IL-1 and IL-1Ra may predispose to local inflammatory disease in particular tissues in the presence of other as yet unknown genetically influenced factors.

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