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Endorphins and extinction: Differential actions on appetitive and adversive tasks

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
24
Issue
18
Identifiers
DOI: 10.1016/0024-3205(79)90245-5

Abstract

Abstract Alpha and gamma endorphin both inhibited the extinction of a runway task for water reward in water-deprived rats after subcutaneous injections of microgram dosages. At similar doses, these same peptides produced opposing actions on the extinction of a pole-jumping avoidance task: alpha endorphin inhibited and gamma endorphin facilitated extinction. The effects of these peptides on motivated behavior may thus be situation-dependent.

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