Affordable Access

Publisher Website

Autonomic and hemodynamic responses and interactions during the Mueller maneuver in humans

Authors
Journal
Journal of the Autonomic Nervous System
0165-1838
Publisher
Elsevier
Publication Date
Volume
44
Identifiers
DOI: 10.1016/0165-1838(93)90038-v
Keywords
  • Blood Pressure
  • Heart Rate
  • Sympathetic Nerve Activity
  • Apnea
Disciplines
  • Medicine

Abstract

Abstract We compared the responses to a Mueller maneuver maintained for 20 s to effects of an equal period of end expiratory apnea. We measured heart rate, mean blood pressure (BP), central venous pressure (CVP), and sympathetic nerve activity (SNA) in 9 normal humans. The Mueller maneuver was accompanied by a fall in CVP from 5 ± 1.2 to − 13 ± 3.2 mmHg ( P < 0.05). During the first 10 s of Mueller, BP fell from 95 ± 4.2 to 81 ± 5.5 mmHg and SNA fell as low as 16 ± 6% of control ( P < 0.05). For the 5 s prior to release SNA increased to 236 ± 36% ( P < 0.05), and BP began to increase. Release of the Mueller resulted in a surge in BP to 104 ± 5.8 mmHg and suppression of SNA to 61 ± 48% ( P < 0.05). By contrast, there was no fall in BP or CVP during apnea and SNA increased to 188 ± 24% for the first 5 s. Between 16 and 20 s of apnea SNA was 231 ± 52% and BP increased from 92 ± 3.1 to 96 ± 3.6 mmHg ( P < 0.05). Release of apnea resulted in a surge in BP to 105 ± 3.0 mmHg and suppression of SNA to 30 ± 12% ( P < 0.05). Oscillations in BP and SNA during the Mueller maneuver may contribute to similar oscillations, and hence cardiovascular consequences, in patients with sleep apnea.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Autonomic and hemodynamic responses and interactio...

on Journal of the autonomic nervo... 1993

Changes in tracheal cross-sectional area during Mu...

on Journal of Applied Physiology June 1986

Autonomic and hemodynamic responses to insulin in...

on The Journal of Clinical Endocr... June 1998

Magnitude and time course of hemodynamic responses...

on Journal of Applied Physiology October 1998
More articles like this..