Affordable Access

Publisher Website

Dimethyl(methylthio)sulfonium tetrafluoroborate: A reagent for disulfide bond formation in peptides

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
34
Issue
28
Identifiers
DOI: 10.1016/0040-4039(93)88061-m

Abstract

Abstract Dimethyl(methylthio)sulfonium tetrafluoroborate ( 1) has been used to deprotect a series of cysteine derivatives (BocCys-Acm, MeOBzl, Trt) with concurrent disulfide bond formation. This reagent has also been applied to the deprotection and disulfide bond formation in two peptides: a sarafotoxin A fragment and an analog of calcitonin where each peptide contains two S-protected cysteine derivatives: [Cys(Acm)]

There are no comments yet on this publication. Be the first to share your thoughts.