Affordable Access

Publisher Website

A thyroxine binding globulin (TBG)-like protein in the sera of developing and adult rats

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
148
Issue
3
Identifiers
DOI: 10.1016/s0006-291x(87)80255-3
Disciplines
  • Biology

Abstract

We report evidence based on equilibrium binding, electrophoretic, autoradiographic studies, that the rat possesses a major high affinity thyroid hormone binding protein, with an electrophoretic mobility and binding properties similar to those of the human thyroxine binding globulin (TBG). We show that in the sera of postnatal developing animals, the thyroxine and the triiodothyronine binding activities increase up to 10 times over adult or foetal levels, due to a high transient post-natal surge of the rat TßG. In the adult serum, the TBG persists in decreased amounts : it then yields the predominant role as thyroxine carrier to the thyroid binding prealbumin, but retains the major role as binder of triiodothyronine i.e. of the biologically active thyroid hormone.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A thyroxine binding globulin (TBG)-like protein in...

on Biochemical and Biophysical Re... Nov 13, 1987

[Thyroxine binding globulin (TBG)].

on Nihon rinsho. Japanese journal... December 1999

[Thyroxine binding globulin (TBG)].

on Nihon rinsho. Japanese journal... March 1995

A senescence up-regulated protein: the rat thyroxi...

on Biochimica et Biophysica Acta... Jan 01, 1991
More articles like this..