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Iron Dienylphosphate Tricarbonyl complexes as water-soluble enzyme-triggered CO-releasing molecules (ET-CORMs)

American Chemical Society
Publication Date
  • Institute Of Inorganic Chemistry
  • 540 Chemistry
  • Biology


A series of racemic phosphoryloxy-substituted (eta(4)-cyclohexadiene)Fe(CO)(3) complexes was synthesized by exploiting the O-phosphorylation of (dienol)Fe(CO)(3) intermediates generated in situ from the corresponding triisopropylsiloxy-protected complexes. The phosphorylated products were fully characterized by spectroscopic methods, including single-crystal X-ray diffraction in four cases. Monodeprotection of two dimethyl phosphate derivatives with trimethylamine led to the tetramethylammonium salts of the (cyclohexadienyl methyl phosphate)Fe(CO)(3) complexes. These compounds are the first water-soluble enzyme-trigged CO-releasing molecules (ET-CORMs). The phosphatase-induced CO release was monitored by means of GC. The biological activity was assessed in different cellular assays. The compounds were shown to be only slightly toxic, and a moderate anti-inflammatory potential was determined in an assay based on the inhibition of inducible NO synthase (iNOS)-induced NO production.

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