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Novel immunological targets in rheumatic diseases: clues from current therapies

Authors
Journal
Drug Discovery Today Disease Mechanisms
1740-6765
Publisher
Elsevier
Identifiers
DOI: 10.1016/j.ddmec.2013.09.002
Disciplines
  • Medicine

Abstract

Many years have passed since the discoveries of immunomodulators as effective therapeutics for the treatment of rheumatic diseases and we are still learning about their various mechanisms of action. Here we provide a concise overview of the most recent discoveries in this field of research, focusing in particular on signaling pathways targeted by therapeutics currently used in the clinic. In doing so, we will highlight areas of investigation that might potentially be explored for the development of new classes of anti-rheumatic drugs.

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