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Fluorogenic substrate assay of antithrombin III: A clinical study

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
31
Issue
6
Identifiers
DOI: 10.1016/0049-3848(83)90116-0
Keywords
  • Antithrombin Iii And Synthetic Substrate
Disciplines
  • Medicine

Abstract

Abstract The fluorogenic substrate assay of antithrombin III (AT III) was compared with a thrombin inhibition (two-stage) clotting test and a radial immunodiffusion assay. Normal ranges based on a population of 25 individuals were 88–121% (fluorogenic substrate), 72–111% (clotting) and 22.5–35.3 mg/dl (RID). A clinical comparison of the methods showed a linear relationship between the fluorogenic substrate and immunologic methods (r = 0.69, p<0.005), as well as between the fluorogenic substrate and clotting methods (r = 0.75, p<0.005). The fluorogenic substrate assay reflected the highest incidence of low AT III levels in all three clinical groups included (36 patients with arteriosclerosis, 18 with fractures and 37 with thrombosis/embolism).

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